L-glutamic acid effect on changes in biochemical parameters of rats intoxicated by carbon tetrachloride

This study aims to explore the ameliorative effects of L-glutamic acid (L-Glu) against carbon tetrachloride (CCl4) toxicity in male rats. Changes activities alanine and aspartate aminotransferases (ALAT, ASAT) were studied tissues blood Concentrations creatinine, triacylglycerol cholesterol also determined experimental animals. Intraperitoneal administration CCl4 rats led changes animals parameters — an increase aminotransferases, levels. At same time, a decrease ALAT activity was observed myocardium spleen intoxicated animals, ASAT their brain, lungs there growth In turn, with additional tetrachloromethane L-Glu mitigation or no change most indicators observed, namely, fluctuated within control values, concentrations did not compared control. Also under action aminoacid, detected lung tissue tissue. The obtained results indicate corrective effect on physiological biochemical intoxication tetrachloride.